Work

How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force

Year: 1997

Type: review

Abstract: The ActA protein is an essential determinant of pathogenicity that is responsible for the actin-based motility of Listeria monocytogenes in mammalian cells and cell-free extracts. ActA appears to control at least four functions that collectively lead to actin-based motility: (1) initiation of actin polymerization, (2) polarization of ActA function, (3) transformation of actin polymerization into a motile force and (4) acceleration of movement mediated by the host protein profilin.

Source: Trends in Microbiology

DOI: 10.1016/s0966-842x(97)01048-2

Authors: Gregory A. Smith, Daniel A. Portnoy

Institutions: Princeton University, University of Pennsylvania

Language: English

Topic: Listeria monocytogenes in Food Safety

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funder: National Institute of Allergy and Infectious Diseases