Work

Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability?

Year: 2005

Type: article

Abstract: MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc's transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability.

Source: Cell Cycle

DOI: 10.4161/cc.4.11.2121

Authors: Chi V. Dang, Feng Li, Linda A. Lee

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute