Get started
Work

Three‐Dimensional Microfluidic Tissue‐Engineering Scaffolds Using a Flexible Biodegradable Polymer

Year: 2005
Type: article
Abstract: Three-dimensional microfluidic networks using a flexible biodegradable polymer have been fabricated using modified microfabrication processes tailored specifically for poly(glycerol-co-sebacate). A model hepatocyte cell line (HepG2) is seeded and perfused in the microfluidic networks to demonstrate cell viability and function, which is maintained in long-term perfusion culture (see Figure; scale bar is 50 μm). The seeded, fully degradable device can potentially be integrated into a patient's existing vasculature in order to restore organ function.
DOI: 10.1002/adma.200500438
Authors: C. J. Bettinger, E. J. Weinberg, K. M. Kulig, J. P. Vacanti, Y. Wang, J. T. Borenstein, R. Langer
Institutions: Draper Laboratory, Massachusetts Institute of Technology, Harvard University, Massachusetts General Hospital, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
Language: English
Open Access status: green
OpenAlex ID: W2091637934
FWCI: 10.36
Cites: 35
Cited by: 292
Related to: 10