Year: 1983
Type: article
Abstract: Fibrocartilage of bovine knee meniscus was analyzed for major and minor collagen constituents. The main fraction (approximately 98%) of pepsin-solubilized collagen consisted of type I with a small proportion (less than 10%) of type III molecules. The minor fraction (1--2%) isolated by salt precipitation could be further resolved into type V collagen that consisted of alpha 1(V) and alpha 2(V) chains and a type II-like molecule with chains that had all the characteristics of the 3 alpha variant of alpha 1(II) found in hyaline cartilage. The articular surface zone of the meniscus appeared 2--3-fold enriched in these minor collagens compared with deeper tissue, though qualitatively the same distinctive collagen phenotype was evident throughout.
Source: FEBS Letters
Authors: David R. Eyre, J.J. Wu
Institution: Harvard University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2091695131