Work

Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase

Year: 2003

Type: article

Abstract: Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in beta cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we report on successful tolerance induction by expressing a modified form of GAD under control of the invariant chain promoter resulting in efficient epitope display. In spite of specific tolerance insulitis and diabetes occurred with normal kinetics indicating that GAD is not an essential autoantigen in the pathogenesis of diabetes.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20030215

Authors: Elmar Jaeckel, Ludger Klein, Natalia Martin-Orozco, Harald von Boehmer

Institutions: Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Joslin Diabetes Center

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2091742355

FWCI: 5.109

Cites: 29

Cited by: 88

Related to: 10