Work

Expression of α4β7 Integrin on Peripheral Blood Memory CD4+ T-Cells After Allogeneic HCT Correlates with Non-Relapse Mortality and Overall Survival

Year: 2012

Type: article

Abstract: Surface expression of α4β7 integrin, a gut-homing lymphocyte trafficking molecule, on peripheral blood memory T-cells has been shown to be increased in patients who develop acute intestinal graft-vs.-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). Decreased expression of α4β7 integrin on regulatory T-cells at engraftment has also been shown to correlate with the development of intestinal GVHD. We hypothesized that α4β7 integrin expressing memory T-cells in the peripheral blood at day +15 and day +30 after HCT would be associated with the development of acute intestinal GVHD and survival outcomes.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.341