Work

Penicillin tolerance of human isolates of group C streptococci

Year: 1981

Type: article

Abstract: Seventeen clinical isolates of group C streptococci were tested for penicillin tolerance. Sixteen of the strains showed penicillin tolerance with a 32-fold or greater difference between the minimal inhibitory concentration and the minimal bactericidal concentration. Synergism was demonstrated with a combination of penicillin and gentamicin for all 17 strains tested. The rate of antibiotic killing was measured for five of the streptococcal strains by using the combination of penicillin and gentamicin. All isolates were killed within 5 h with the combination, but viable organisms were recovered after 48 h when either drug was used alone. Our study suggests that penicillin tolerance with group C streptococci may occur frequently and may account for the poor outcome of serious group C streptococcal infections tested with penicillin alone.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.20.2.235

Authors: D Portnoy, J Prentis, G K Richards

Institution: Montreal General Hospital

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2091872585

FWCI: 5.294

Cites: 17

Cited by: 48

Related to: 10