Work

Tumor necrosis factor‐α and its role as a mediator in myocardial infarction: A brief review

Year: 2015

Type: review

Abstract: Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI.

Source: Chronic Diseases and Translational Medicine

DOI: 10.1016/j.cdtm.2015.02.002

Authors: Ming Tian, Yun‐Chuan Yuan, Jia‐Yi Li, Michael R. Gionfriddo, Rong‐Chong Huang

Institutions: First Affiliated Hospital of Dalian Medical University, Chongqing Three Gorges Central Hospital, Mayo Clinic

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China