Work

Ultrasound-induced release of micropallets with cells

Year: 2012

Type: article

Abstract: Separation of selected adherent live cells attached on an array of microelements, termed micropallets, from a mixed population is an important process in biomedical research. We demonstrated that adherent cells can be safely, selectively, and rapidly released from the glass substrate together with micropallets using an ultrasound wave. A 3.3-MHz ultrasound transducer was used to release micropallets (500 μm × 500 μm × 300 μm) with attached HeLa cells, and a cell viability of 92% was obtained after ultrasound release. The ultrasound-induced release process was recorded by a high-speed camera, revealing a proximate velocity of ∼0.5 m/s.

Source: Applied Physics Letters

DOI: 10.1063/1.4757648

Authors: Sijia Guo, Yuli Wang, Nancy Allbritton, Xiaoning Jiang

Institutions: University of North Carolina at Chapel Hill, North Carolina State University

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering