Work

Stereospecific Formation of a Ternary Complex of (S)‐α,β‐Fluoromethylene‐dATP with DNA Pol β

Year: 2012

Type: article

Abstract: The influence of water: crystallization of (R/S)-α,β-CHF-dATP with the preorganized pol β-DNA complex shows that (S)-α,β-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.

Source: ChemBioChem

DOI: 10.1002/cbic.201100738

Authors: Brian T. Chamberlain, Vinod K. Batra, William A. Beard, Anastasia P. Kadina, David D. Shock, Boris A. Kashemirov, Charles E. McKenna, Myron F. Goodman, Samuel H. Wilson

Institutions: University of Southern California, National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences

Awards: Biology of Mammalian Base Excision Repair and HIV-1 Replication, Mechanisms of Nucleic Acid Enzymes - Pol Beta and Mammalian Base Repair Enzymes, DNA Polymerase Fidelity Mechanisms: Theory and Experiment

OpenAlex ID: W2092077976

FWCI: 1.93

Cites: 19

Cited by: 30

Related to: 5