Cortical substrates and functional correlates of auditory deviance processing deficits in schizophrenia
Year: 2014
Type: article
Study design: Observational Study
Abstract: Although sensory processing abnormalities contribute to widespread cognitive and psychosocial impairments in schizophrenia (SZ) patients, scalp-channel measures of averaged event-related potentials (ERPs) mix contributions from distinct cortical source-area generators, diluting the functional relevance of channel-based ERP measures. SZ patients (n = 42) and non-psychiatric comparison subjects (n = 47) participated in a passive auditory duration oddball paradigm, eliciting a triphasic (Deviant-Standard) tone ERP difference complex, here termed the auditory deviance response (ADR), comprised of a mid-frontal mismatch negativity (MMN), P3a positivity, and re-orienting negativity (RON) peak sequence. To identify its cortical sources and to assess possible relationships between their response contributions and clinical SZ measures, we applied independent component analysis to the continuous 68-channel EEG data and clustered the resulting independent components (ICs) across subjects on spectral, ERP, and topographic similarities. Six IC clusters centered in right superior temporal, right inferior frontal, ventral mid-cingulate, anterior cingulate, medial orbitofrontal, and dorsal mid-cingulate cortex each made triphasic response contributions. Although correlations between measures of SZ clinical, cognitive, and psychosocial functioning and standard (Fz) scalp-channel ADR peak measures were weak or absent, for at least four IC clusters one or more significant correlations emerged. In particular, differences in MMN peak amplitude in the right superior temporal IC cluster accounted for 48% of the variance in SZ-subject performance on tasks necessary for real-world functioning and medial orbitofrontal cluster P3a amplitude accounted for 40%/54% of SZ-subject variance in positive/negative symptoms. Thus, source-resolved auditory deviance response measures including MMN may be highly sensitive to SZ clinical, cognitive, and functional characteristics.
Source: NeuroImage Clinical
Institutions: University of California San Diego, Japan Society for the Promotion of Science, Swartz Center for Computational Neuroscience, University of California, Los Angeles, Mental Illness Research, Education and Clinical Centers, VA Greater Los Angeles Healthcare System, VA San Diego Healthcare System
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funders: U.S. Department of Veterans Affairs, National Alliance for Research on Schizophrenia and Depression, Veterans Medical Research Foundation, National Institutes of Health, Japan Society for the Promotion of Science, Office of Naval Research, National Institute of Mental Health, NIH Clinical Center, National Center for Advancing Translational Sciences
Awards: Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia, G1772779247, G180240944, SENSORY GATING AND HABITUATION IN SCHIZOPHRENIA, G3532778661, San Diego Clinical and Translational Research Institute, G428829556, G4560442196, G4738887893, Gating and Inhibiting in Schizophrenia, G5259292030, G5407207395, G6414023616, Memantine effects on sensorimotor gating and neurocognition in schizophrenia, 1/6-The Genetics of Endophenotypes and Schizophrenia, 6/9-Predictors and Mechanisms of Conversion to Psychosis, Pathway(s) From Genes to Functional Deficits of Schizophrenia Patients, G8162276840, Fellowship in Geriatric Mental Health
OpenAlex ID: W2092083767