Work

Asymmetric Synthesis of Tertiary Benzylic Alcohols

Year: 2010

Type: article

Abstract: Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.

Source: Organic Letters

DOI: 10.1021/ol102567h

Authors: Monika I. Antczak, Feng Cai, Joseph M. Ready

Institution: The University of Texas Southwestern Medical Center

Language: Polish

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Amgen, National Institutes of Health, National Institute of General Medical Sciences

Award: Catalytic Synthesis of alpha-Branched Carbonyl Compounds