Work

jun-D: a third member of the jun gene family.

Year: 1989

Type: article

Abstract: The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding a third member of the murine jun family, jun-D. The amino acid sequence encoded by jun-D has two extensive regions of homology with the other Jun proteins. One homology region includes the DNA-binding domain and sequences required for dimer formation and interaction with the Fos oncoprotein; the other includes the acidic sequence thought to be involved in gene activation. All three jun mRNAs are present in a variety of murine tissues and cell lines. In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors. Thus, jun-D appears to be regulated differently than c-jun and jun-B.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.86.5.1500

Authors: K Ryder, A Lanahan, E Perez-Albuerne, D Nathans

Institutions: Howard Hughes Medical Institute, Johns Hopkins University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: American Cancer Society, National Cancer Institute, National Institute of General Medical Sciences

Awards: Medical Scientist Training Program, Program on Molecular and Cellular Mechanisms of Tumorigenesis