Year: 1997
Type: article
Abstract: NAKAMURA, I., M. SAITO, Y. FUKUMOTO, M. YOSHIDA, K. NISHI, R. M. WEISS AND J. LATIFPOUR. Experimental diabetes upregulates the expression of uretereral endothelin receptors. PEPTIDES 18(7) 1091–1093, 1997.—We investigated the binding characteristics of endothelin (ET) receptors in the ureters of rats with experimentally induced diabetes and diuresis. Receptor binding experiments demonstrated an upregulation in the expression of [125I]ET-1 binding sites in the diabetic rat ureter but not in the diuretic rat ureter. ET-1, ET-3, IRL 1620, and BQ 610 inhibited [125I]ET-binding to the rat ureter consistent with the predominance of ETA receptors in these tissues. The subtype specificity of ET receptors in ureteral tissues was confirmed with inhibition data obtained from cloned human ETA and ETB receptors.
Source: Peptides
Authors: Isao Nakamura, Motoaki Saito, Yuji Fukumoto, Masaki Yoshida, Kazuhiko Nishi, Robert M Weiss, Jamshid Latifpour
Institution: Yale University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,710
OpenAlex ID: W2092286749