Work

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

Year: 1998

Type: review

Abstract: Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of signaling molecules can assemble to generate preassembled signaling complexes. In addition to concentrating these signal transducers within a distinct region of the plasma membrane, caveolin binding may functionally regulate the activation state of caveolae-associated signaling molecules. Because the responsibilities assigned to caveolae continue to increase, this review will focus on: (i) caveolin structure/function and (ii) caveolae-associated signal transduction.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.273.10.5419

Authors: Takashi Okamoto, Amnon Schlegel, Philipp E. Scherer, Michael P. Lisanti

Institutions: Cleveland Clinic, Albert Einstein College of Medicine, Yeshiva University

Language: English

Topic: Caveolin-1 and cellular processes

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institute of Mental Health, National Institute of General Medical Sciences