Year: 2008
Type: review
Abstract: The N-glycan-dependent quality control mechanism of glycoprotein folding was proposed initially by Helenius and co-workers several years ago; with a few minor modifications, it is still valid today (Fig. 1) (1–3).2 Glycan processing starts immediately after its transfer from a dolichol-P-P derivative to Asn residues in nascent polypeptide chains entering the lumen of the ER.3 Removal of the outermost and following glucoses by the successive action of GI and GII exposes the Glc1Man9GlcNAc2 epitope (Fig.
Source: Journal of Biological Chemistry
Authors: Julio J. Caramelo, Armando J. Parodi
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2092645001