Work

Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC‐NPC Culture

Year: 2014

Type: article

Abstract: Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201400410

Authors: Jonathan Lam, S. Thomas Carmichael, William E. Lowry, Tatiana Segura

Institutions: University of California, Los Angeles, Broad Center

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke