Work

Haploidentical Bone Marrow Transplantation Using Anti-CD45 Radioimmunotherapy to Decrease Relapse in a Pre-Clinical Murine Model

Year: 2012

Type: article

Abstract: Allogeneic hematopoietic cell transplant (HCT) is a widely used therapy for hematologic malignancy. It is important to give the option of HCT to patients without an HLA-matched donor; this is most acute for ethnic minorities. Haploidentical HCT may offer the best or only chance for cure but often fails due to persistant malignancy or fatal toxicity. It is important to improve disease control without increased toxicity of the regimen. We have shown that CD45 radioimmunotherapy (RIT) delivers radiation to leukemic sites, sparing normal organs.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.062