Work

Angiotensinogen Gene Transcription in Pulmonary Fibrosis

Year: 2012

Type: article

Abstract: An established body of literature supports the hypothesis that activation of a local tissue angiotensin (ANG) system in the extravascular tissue compartment of the lungs is required for lung fibrogenesis. Transcriptional activation of the angiotensinogen (AGT) gene is believed to be a critical and necessary step in this activation. This paper summarizes the data in support of this theory and discusses transcriptional regulation of AGT, with an emphasis on lung AGT synthesis as a determinant of fibrosis severity. Genetic data linking AGT polymorphisms to the severity of disease in Idiopathic Pulmonary Fibrosis are also discussed.

Source: International Journal of Peptides

DOI: 10.1155/2012/875910

Authors: Bruce D. Uhal, My-Trang T. Dang, Xiaopeng Li, Amal Abdul-Hafez

Institutions: Michigan State University, University of Iowa, Misr International University

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2092876503