Work

Eye regeneration at the molecular age

Year: 2003

Type: review

Abstract: Eye tissues such as the lens and the retina possess remarkable regenerative abilities. In amphibians, a complete lens can be regenerated after lentectomy. The process is a classic example of transdifferentiation of one cell type to another. Likewise, retina can be regenerated, but the strategy used to replace the damaged retina differs, depending on the animal system and the age of the animal. Retina can be regenerated by transdifferentiation or by the use of stem cells. In this review, we present a synthesis on the regenerative capacity of eye tissues in different animals with emphasis on the strategy and the molecules involved. In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.10224

Authors: Katia Del Rio‐Tsonis, Panagiotis A. Tsonis

Institutions: University of Dayton, Miami University

Language: English

Topic: Retinal Development and Disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Eye Institute

Awards: Molecular Pathway in Retina Regeneration, Gene Regulation in Lens Regeneration