Work

Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments

Year: 2013

Type: review

Abstract: Primary non-motile cilia and dendritic spines are cellular compartments that are specialized to sense and transduce environmental cues and presynaptic signals, respectively. Despite their unique cellular roles, both compartments exhibit remarkable parallels in the general principles, as well as molecular mechanisms, by which their protein composition, membrane domain architecture, cellular interactions, and structural and functional plasticity are regulated. We compare and contrast the pathways required for the generation and function of cilia and dendritic spines, and suggest that insights from the study of one may inform investigations into the other of these critically important signaling structures.

Source: Molecules and Cells

DOI: 10.1007/s10059-013-0246-z

Authors: Inna V. Nechipurenko, David B. Doroquez, Piali Sengupta

Institution: Brandeis University

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,500

Funder: National Institute of General Medical Sciences