Work

Anilinomethylrhodamines: pH Sensitive Probes with Tunable Photophysical Properties by Substituent Effect

Year: 2013

Type: article

Abstract: A series of pH dependent rhodamine analogues possessing an anilino-methyl moiety was developed and shown to exhibit a unique photophysical response to pH. These anilinomethylrhodamines (AnMR) maintain a colorless, nonfluorescent spirocyclic structure at high pH. The spirocyclic structures open in mildly acidic conditions and are weakly fluorescent; however, at very low pH, the fluorescence is greatly enhanced. The equilibrium constants of these processes show a linear response to substituent effects, which was demonstrated by the Hammett equation.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo401323g

Authors: Quinn A. Best, Chuangjun Liu, Paul D. van Hoveln, Matthew E. McCarroll, Colleen N. Scott

Institution: Southern Illinois University Carbondale

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Design and evaluation of response selective fluorescent sensors