Work

CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV‐1 Encephalitis

Year: 2006

Type: article

Abstract: CD45 is a membrane tyrosine phosphatase that modulates the function of the hematopoietic cells. In vitro, agonist antibodies to CD45RO or CD45RB isoforms have been shown to suppress microglial activation, but whether microglia in vivo express these isoforms in HIV encephalitis (HIVE) is unknown. Brain sections from control and HIVE were immunostained for CD45 isoforms using exon-specific antibodies (RA, RB, RC and RO). RA and RC were limited to rare lymphocytes, while RB expression was robust in microglia and inflammatory cells. RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases.

Source: Brain Pathology

DOI: 10.1111/j.1750-3639.2006.00027.x

Authors: Melissa A. Cosenza‐Nashat, Mee‐Ohk Kim, Meng‐Liang Zhao, Hyeon‐Sook Suh, Sunhee C. Lee

Institutions: City University of New York, Massachusetts General Hospital, Albert Einstein College of Medicine

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke