Year: 2014
Type: article
Abstract: Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it varies drastically among the tumors' origins, stages, and organs, owing much to differences in vessel leakiness. Suboptimal EPR effect represents a major problem in the translation of nanomedicine to the clinic. In the present study, we introduce a photodynamic therapy (PDT)-based EPR enhancement technology. The method uses RGD-modified ferritin (RFRT) as "smart" carriers that site-specifically deliver (1)O2 to the tumor endothelium. The photodynamic stimulus can cause permeabilized tumor vessels that facilitate extravasation of nanoparticles at the sites. The method has proven to be safe, selective, and effective. Increased tumor uptake was observed with a wide range of nanoparticles by as much as 20.08-fold. It is expected that the methodology can find wide applications in the area of nanomedicine.
Source: ACS Nano
DOI: 10.1021/nn501134q
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: National Science Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research, National Center for Research Resources
Awards: G4727740710, G4952910785, Robo4 and heparan sulfate proteoglycan in angiogenesis, Resource for Integrated Glycotechnology, Resource for Integrated Glycotechnology, G596277974, G6671297155, CAREER: Synthesis and Characterization of Novel Rare-Earth-Activated One-Dimensional Luminescent Nanostructures, G791517991, G806109369, G8978887696, G9000333702
OpenAlex ID: W2093258954