Work

Shedding Light on Melanocyte Pathobiology In Vivo

Year: 2012

Type: article

Abstract: Cutaneous malignant melanoma is rapidly increasing in the developed world and continues to be a challenge in the clinic. Although extensive epidemiologic evidence points to solar UV as the major risk factor for melanoma, there is a significant gap in our knowledge about how this most ubiquitous environmental carcinogen interacts with the largest organ of the mammalian body (skin) at the microenvironmental and molecular level. We review some recent advances that have started to close this gap.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-11-2586

Authors: M. Raza Zaidi, Edward C. De Fabo, Frances P. Noonan, Glenn Merlino

Institutions: National Institutes of Health, George Washington University, National Cancer Institute

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute