Work

Are the presynaptic membrane particles the calcium channels?

Year: 1981

Type: article

Abstract: The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0.21 pS, compares favorably with conductances of calcium channels in other preparations, substantiating the idea that the large intramembrane particles, which are concentrated at "active zones," represent calcium channels.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.78.11.7210

Authors: D W Pumplin, T S Reese, R Llinás

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2093441174

FWCI: 3.703

Cites: 17

Cited by: 316

Related to: 10