Work

SOCS proteins, cytokine signalling and immune regulation

Year: 2007

Type: review

Abstract: In this Review, Akihiko Yoshimura and collegues discuss the most recent advances in our understanding of suppressor of cytokine signalling (SOCS) proteins in the regulation of immunity, their involvement in human diseases and the therapeutic implications of targeting this family of cytokine regulators. Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling pathways. Studies have shown that SOCS proteins are key physiological regulators of both innate and adaptive immunity. These molecules positively and negatively regulate macrophage and dendritic-cell activation and are essential for T-cell development and differentiation. Evidence is also emerging of the involvement of SOCS proteins in diseases of the immune system. In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function.

Source: Nature reviews. Immunology

DOI: 10.1038/nri2093

Authors: Akihiko Yoshimura, Tetsuji Naka, Masato Kubo

Institutions: Kyushu University, Medical Institute of Bioregulation, Kyushu University, National Institute of Biomedical Innovation, RIKEN

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2093442991

FWCI: 6.941

Cites: 113

Cited by: 1,620

Related to: 10