Work

Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon

Year: 2009

Type: article

Abstract: Background The human immunodeficiency virus type 1 (HIV-1) encodes the 110 amino acid-pleiotropic nuclear transcriptional activator Tat that is not only essential for efficient elongation of viral transcripts, but also regulates both cellular protein and gene expression. Tat encoding gene consists of two spliced exons separated in the HIV-1 genome by more than 2.300 nucleotides. First 72 residues at the Nterminal encoded by the first exon appear to be sufficient for transcriptional activity, but the integrity of the coding second exon in most lentiviral genomes suggests that it should have some biological importance. In this work, we demonstrate that the second exon completes Tat function.

Source: Retrovirology

DOI: 10.1186/1742-4690-6-s2-p1

Authors: María Rosa López-Huertas, Sergio Callejas, David Abia, Ana Dopazo, José Alcamí, Mayte Coiras

Institutions: Instituto de Salud Carlos III, Centro Nacional de Microbiologia, Spanish National Centre for Cardiovascular Research, Consejo Superior de Investigaciones Científicas, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,890

OpenAlex ID: W2093575818

FWCI:

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