Work

Ceramide‐rich platforms in transmembrane signaling

Year: 2010

Type: review

Abstract: Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2010.02.026

Authors: Branka Stancevic, Richard Kolesnick

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute

Award: Modulation of Ceramide Induced Apoptosis in Vivo