Work

Stem Cell Niche: Microenvironment and Beyond

Year: 2008

Type: article

Abstract: The multipotentiality and self-renewal ability of stem cells are controlled by intrinsic genetic pathways that are subject to regulation by extrinsic signals emanating from the stem cell niche. The stem cell niche provides a microenvironment composed of cellular structures or extracellular matrix in which stem cells are maintained as undifferentiated (1–6). The concept of “the stem cell niche” was first proposed in studies of the HSC2 (7); however, in vivo evidence of its existence was first shown in the Drosophila GSC (8–10).

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r700043200

Authors: Jiwang Zhang, Linheng Li

Institutions: Loyola University Medical Center, Loyola University Chicago, Stowers Institute for Medical Research, University of Kansas Medical Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W2093720544

FWCI: 8.395

Cites: 103

Cited by: 135

Related to: 10