Work

Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates

Year: 1999

Type: article

Abstract: Siderophores are microbial iron chelating agents that sequester physiologically essential iron for microbes. Conjugation of drugs to siderophores allows use of active iron transport for microbially directed drug delivery. Syntheses and biological studies are described of the first multidrug isocyanurate-based siderophore analogues separately containing one, two, and three 5-fluorouridine (5-FU) derivatives as the drug component. The results indicate that a single siderophore can be used to deliver multiple drugs to target pathogenic microorganisms.

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/s0968-0896(99)00248-5

Authors: Yong Lu, Marvin J Miller

Institution: University of Notre Dame

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,960