Work

Facile DNA Immobilization on Surfaces through a Catecholamine Polymer

Year: 2010

Type: article

Abstract: Simple immersion of noble metals, oxides, semiconductors, and synthetic polymer substrates in a mussel-mimetic catecholamine polymer solution p(DOMA-AEMA) leads to formation of a thin film on the substrate. The resulting coated substrates can bind DNA without further surface treatment. This approach provides a new entrance to DNA microarray fabrication.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201005001

Authors: Hyun Ok Ham, Zhongqiang Liu, K. H. Aaron Lau, Haeshin Lee, Phillip B. Messersmith

Institutions: Northwestern University, Korea Advanced Institute of Science and Technology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chemistry of Life Processes Institute

Language: English

Topic: Polymer Surface Interaction Studies

Subfield: Surfaces, Coatings and Films

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research

Award: Biologically Inspired Polymer Adhesives