Work

Genes, environment, and lifespan: new insights into Niemann-Pick C disease

Year: 2008

Type: article

Abstract: It is well recognized by mouse geneticists that genetic background can play a critical role in determining responses of phenotypic traits to specific gene mutations, deletions, or insertions (for an excellent review of this subject, see Ref. 1). It is also generally recognized by clinicians that humans with diseases due to mutation in a single gene often show wide variability in disease course and severity. However, it has been underappreciated in the general biomedical/biotechnology research communities that factors other than a gene mutation, deletion, insertion, per se can be major determinants of phenotypic traits.

Source: Journal of Lipid Research

DOI: 10.1194/jlr.e800002-jlr200

Author: Sandra K. Erickson

Institution: University of California, San Francisco

Language: English

Topic: Lysosomal Storage Disorders Research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430