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Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells

Year: 2014
Type: conference-abstract
Abstract: Meeting abstracts ALT-801, a fusion of interleukin-2 and a single-chain T cell receptor domain specific to a p53 peptide/HLA-A*0201 complex, has shown immune cell-mediated activity in human xenograft tumor SCID mouse models and in patients with metastatic malignancies. To further investigate the
DOI: 10.1186/2051-1426-2-s3-p123
Authors: Wenxin Xu, Jack O Egan, Bai Liu, Xiaoyue Chen, Lijing You, Kaiping Han, Warren D Marcus, Lin Kong, Monica Jones, Emily K Jeng, Peter R Rhode, Hing C Wong
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,490
OpenAlex ID: W2093892510
Cites:
Cited by: 1
Related to: 10