Work

Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice

Year: 1992

Type: article

Abstract: Milacemide, an acylated prodrug of glycine, was able to increase the efficacy with which [+]-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine meleate (MK 801) antagonized the electrical precipitation of seizures in mice. The mechanism of milacemide's potentiation of MK 801's antiseizure efficacy in intact mice is unclear; however, a glycine agonist selective for the strychnine-insensitive site on the NMDA receptor complex was also able to potentiate MK 801. The exciting possibility exists that an exogenous glycinergic intervention can potentiate NMDA-mediated neural transmission in intact animals.

Source: Pharmacology Biochemistry and Behavior

DOI: 10.1016/0091-3057(92)90198-o

Authors: Deborah O. Norris, John Mastropaolo, David A. O'Connor, Monica R. Novitzki, Stephen I. Deutsch

Institutions: United States Department of Veterans Affairs, American University, Georgetown University, Veterans Health Administration, Washington DC VA Medical Center

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650