Work

Functional analysis of the human neurofilament light chain gene promoter

Year: 1993

Type: article

Abstract: We have carried out a structural and functional analysis on the human NF-L (H-NF-L) gene. It contains a methylation-free island, spanning the 5' flanking sequences and the first exon and a number of neuronal-specific DNase I hypersensitive sites have been identified in the upstream region as well as within the body of the gene. Analysis in cell lines and transgenic mice using a combination of these sites has revealed the presence of a conserved element(s) between -300bp and -190bp which is required for neuronal-specific expression.

Source: Nucleic Acids Research

DOI: 10.1093/nar/21.3.455

Authors: Karma Yazdanbakhsh, Peter Fraser, Dimitris Kioussis, Miguel Vidal, Frank Grosveld, Mike Lindenbaum

Institution: National Institute for Medical Research

Language: English

Topic: Skin and Cellular Biology Research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Medical Research Council