Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy
Year: 2011
Type: article
Study design: Observational Study
Abstract: Conflicting prevalence of newly identified KI (KIPyV), WU (WUPyV) and Merkel Cell Carcinoma (MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy (PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence of these polyomaviruses in cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMC), and bone marrow samples from PML patients, immunosuppressed individuals with or without HIV, and multiple sclerosis (MS) patients. Distinct PCR tests for KIPyV, WUPyV and MCPyV DNA performed in two independent laboratories detected low levels of MCPyV DNA only in 1/269 samples. The infrequent detections of these viruses in multiple samples from immunosuppressed individuals including those with PML suggest that their reactivation mechanisms may be different from that of JC polyomavirus (JCPyV) and that they do not play a role in the pathogenesis of PML.
Source: PLoS ONE
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G4700852728, Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy, Role of Inflammation in Progressive Multifocal Leukoencephalopathy, Translational applications of Progressive Multifocal Leukoencephalopathy studies, G8004881717, Harvard University Center for AIDS Research, Infectious Disease and Basic Microbiological Mechanisms, JC Virus Primary Infection, Latency, and Reactivation
OpenAlex ID: W2094052994