Work

Channel-forming toxins: tales of transformation

Year: 1997

Type: review

Abstract: Channel-forming bacterial toxins undergo a series of remarkable changes in solubility, oligomerization state, structure and dynamics during the processes of membrane binding, assembly, membrane insertion and channel formation. Recent high-resolution crystal structures of channel-forming toxins, in both water-soluble and membrane-bound, channel-formed states, have brought a wealth of new information to bear on issues of structure, mechanism and function.

Source: Current Opinion in Structural Biology

DOI: 10.1016/s0959-440x(97)80123-6

Author: Eric Gouaux

Institution: Columbia University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,360

Funders: National Science Foundation, National Institutes of Health, Office of Naval Research