How the Noninflammasome NLRs Function in the Innate Immune System
Year: 2010
Type: review
Abstract: NLR (nucleotide-binding domain, leucine-rich repeat-containing) proteins have rapidly emerged as central regulators of immunity and inflammation with demonstrated relevance to human diseases. Much attention has focused on the ability of several NLRs to activate the inflammasome complex and drive proteolytic processing of inflammatory cytokines; however, NLRs also regulate important inflammasome-independent functions in the immune system. We discuss several of these functions, including the regulation of canonical and noncanonical NF-kappaB activation, mitogen-activated protein kinase activation, cytokine and chemokine production, antimicrobial reactive oxygen species production, type I interferon production, and ribonuclease L activity. We also explore the mechanistic basis of these functions and describe current challenges in the field.
Source: Science
Authors: Jenny P. Y. Ting, Joseph A. Duncan, Yu Lei
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Regulation of the physiologic and pathologic activation of the NLRP3-inflammasome, G1430450742, M Tuberculosis and Host-Defense Mechanisms, Southeastern Sexually Transmitted Infections Cooperative Research Center, Plexin-A1: Regulation by CIITA and Immunologic Function, Pathophysiology of Renal Allograft Dysfunction, G4944907048, Innate Immune Response Genes and P. Gingivalis, Nucleotide Binding in NOD2-Mediated Inflammation and Carcinogenesis, Immunobiology of Acute Environmental Asthma, Southeast Regional Centers of Excellence for Biodefense & Emerging Infectious Di
OpenAlex ID: W2094129507