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Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations

Year: 2012
Type: article
Abstract: Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.
DOI: 10.1128/aac.06160-11
Authors: Yanhui Lu, Connie Celum, Anna Wald, Jared M. Baeten, Frances Cowan, Sinead Delany-Moretlwe, Stewart E. Reid, James P. Hughes, Ellen Wilcox, Lawrence Corey, Craig W. Hendrix
Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Washington, University of Zimbabwe, University College London, University of the Witwatersrand, Centre for Infectious Disease Research in Zambia, University of Alabama at Birmingham
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: green
OpenAlex ID: W2094251467
FWCI: 1.91
Cites: 21
Cited by: 24
Related to: 10