Work

Harnessing FOXP3+ regulatory T cells for transplantation tolerance

Year: 2014

Type: review

Abstract: Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci67226

Authors: Herman Waldmann, Robert Hilbrands, Duncan Howie, Stephen Cobbold

Institution: University of Oxford

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Molecular Biology Organization, University of Oxford