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Evolving Concepts in Lung Carcinogenesis

Year: 2011
Type: article
Abstract: Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the "field of cancerization," and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer.
DOI: 10.1055/s-0031-1272867
Authors: Brigitte Gomperts, Avrum Spira, Pierre Massion, Tonya Walser, Ignacio Wistuba, John Minna, Steven Dubinett
Institutions: University of Southern California, University of California, Los Angeles, Boston University, Vanderbilt University, Nashville VA Medical Center, Vanderbilt-Ingram Cancer Center, The University of Texas MD Anderson Cancer Center, The University of Texas Southwestern Medical Center
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
OpenAlex ID: W2094286079
FWCI: 3.942
Cites: 130
Cited by: 70
Related to: 10