Work

Signal transduction through lipid second messengers

Year: 1996

Type: review

Abstract: This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.

Source: Current Opinion in Cell Biology

DOI: 10.1016/s0955-0674(96)80061-5

Authors: Sarah Spiegel, David Foster, Richard Kolesnick

Institutions: Georgetown University Medical Center, City University of New York, Hunter College, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funders: National Cancer Institute, National Institute of General Medical Sciences