Work

Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

Year: 2014

Type: review

Abstract: Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF- κ B and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.

Source: BioMed Research International

DOI: 10.1155/2014/807635

Authors: Keliang Xie, Lingling Liu, Yonghao Yu, Guolin Wang

Institutions: Tianjin Medical University General Hospital, Tianjin Medical University

Language: English

Topic: Hydrogen's biological and therapeutic effects

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680