Work

The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor

Year: 1996

Type: article

Abstract: In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1996.tb15718.x

Authors: Astrid Parenti, Sandra Donnini, Lucia Morbidelli, Harris J. Granger, Marina Ziche

Institutions: University of Florence, Texas A&M Health Science Center, Texas A&M University

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2094466319

FWCI: 0.884

Cites: 10

Cited by: 20

Related to: 10