Work

Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

Year: 2006

Type: article

Abstract: Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit).

Source: Neurology

DOI: 10.1212/01.wnl.0000208433.34723.65

Authors: A. B. Ragin, Y. Wu, P. Storey, B. A. Cohen, R. R. Edelman, L. G. Epstein

Institution: Northwestern University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, National Institute of Neurological Disorders and Stroke