Work

Conversion of L ‐tryptophan to serotonin and melatonin in human melanoma cells

Year: 2002

Type: article

Abstract: We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(01)03319-1

Authors: Andrzej Slominski, Igor Semak, Alexander Pisarchik, Trevor Sweatman, Andre Szczesniewski, Jacobo Wortsman

Institutions: University of Tennessee Health Science Center, Belarusian State University, SIU Medicine

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2094482985

FWCI: 1.493

Cites: 15

Cited by: 163

Related to: 10