Release of Newly Synthesized Dopamine From Dopamine-containing Terminals in the Striatum of the Rat
Year: 1969
Type: article
Abstract: The extraneuronal spontaneous efflux of (3)H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the (3)H amine in superfusates of isolated striatum of the rat previously incubated with (3)H-tyrosine. The (3)H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of (3)H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.
Authors: M. J. Besson, A. Cheramy, P. Feltz, J. Glowinski
Institution: Collège de France
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2094543793