Year: 2011
Type: article
Abstract: A metallo-β-lactamase-type alkylsulfatase was found to catalyze the enantioselective hydrolysis of sec-alkylsulfates with strict inversion of configuration. This catalytic event, which does not have an analog in chemocatalysis, yields homochiral (S)-configurated alcohols and nonreacted sulfate esters. The latter could be converted into (S)-sec-alcohols as the sole product in up to >99% ee via a chemoenzymatic deracemization protocol on a preparative scale.
Source: Organic Letters
DOI: 10.1021/ol201635y
Authors: Markus Schober, Petra Gadler, Tanja Knaus, Heidemarie Kayer, Ruth Birner-Grünberger, Christian Gülly, Peter Macheroux, Ulrike Wagner, Kurt Faber
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2094587578