Work

385. Tol2 Transposon as a Gene Therapy Vector: Characterization, Optimization and Correction of Hereditary Tyrosinemia Type 1 in Mouse

Year: 2006

Type: article

Abstract: To expand the repertoire of transposable elements available for gene transfer in higher vertebrates, we investigated the properties of the Tol2 transposon in mammalian cells and in vivo. Tol2 is a member of the hAT family of DNA transposons and is derived from an active element found in the tyrosinase gene of medaka fish (Oryzias latipes). Tol2 can transpose in mouse ES cells, suggesting its potential use as a gene transfer reagent in higher vertebrates.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.446

Authors: Darius Balciunas, Andrew Wilber, Kirk Wangensteen, Jason Bell, Aron Geurts, Perry B. Hackett, David A. Largaespada, R. Scott McIvor, Stephen C. Ekker

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

OpenAlex ID: W2094718259

FWCI:

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